Aging Overview

Aging gene

Gene name: MIR181A1
Aging type: Accelerate
Aging characteristic:
Tissue type: --
Cell name: CD4+T
Gene ID: 406995
Category: ncRNA
Phenotype: HCV infection
Experimental category: L
PMID: 27354409
Experiment: SA-β-gal activity assay//EdU assay
Description: MiR-181a reconstitution significantly reduced the telomere length, increased SA-β-gal+ T cell frequency, and decreased EdU incorporation, in CD4+ T cells from patients with HCV.


Regulatory relationship

Target gene: SIRT1
Official symbol(s): SIRT1
R-AG-Target gene: Downregulation
Subcategory: Unclear
Target gene experiment: Flow cytometry
Target gene description: Transfection of miR-181a precursor, but not the negative control, led to a significant down-regulation of Sirt1 expression in CD4+ T cells.

Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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