| Gene name: | CDK2 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | BJ |
| Experiment: | Immunostaining//SA-β-gal activity assay//Western blot |
| Description: | Indeed, in both human BJ fibroblasts and in MEFs, constitutive ectopic expression of CDK2 abrogated senescence in response to either DNA damage (irradiation), or oncogenic stress (HRasV12 transduction), as evidenced by continued proliferation by day 14 and absence of SABG staining,along with reduction in other protein markers of senescence. |
| Target gene: | P53//RB |
| Official symbol(s): | P53//RB |
| R-AG-Target gene: | --//-- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot//qPCR |
| Target gene description: | The lack of repression of CDK2 in p53-null cells and tissues suggested that CDK2 down-regulation is a downstream consequence of p53 activation.As expected, genetic ablation of Rb resulted in increased baseline protein levels of Cdk2. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
Loading,please wait...