| Gene name: | KDR |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | Colon |
| Cell name: | -- |
| Gene ID: | 3791 |
| Category: | protein coding |
| Phenotype: | Colitis associated cancer |
| Experimental category: | L |
| PMID: | 25797700 |
| Experiment: | SA-β-gal activity assay//Western blot//Immunostaining |
| Description: | Specifically, senescence-associated beta-galactosidase (S-β-Gal) and the cyclin-dependent kinase inhibitor p16INK4A, were significantly upregulated in tumors of VEGFR2 IEC mice compared to controls.Altered tissue of VEGFR2?IEC mice revealed stronger expression of γH2A.X when compared to control mice using WB and IHC analysis. |
| Target gene: | P21 |
| Official symbol(s): | P21 |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Immunostaining//Western blot |
| Target gene description: | We observed a significant difference in p21 protein expression in tumors of VEGFR2-deficient mice compared to control mice, as assessed by Western blotting and IHC.Moreover, not only the overall concentration of p21 was distinctively upregulated in tumors of VEGFR2 IEC mice, but also a predominant nuclear staining pattern could be observed. |
| Regulatory pathway: | PI3K-AKT |
| R-AG-Pathway: | -- |
| Official symbol(s): | PIK3CA-AKT1 |
| Pathway experiment: | Co-IP |
| Pathway description: | Using co-immunoprecipitation we were able to show an interaction of VEGFR2 and PI3K as well as AKT and p21, consistent with the idea of a functional connection of these molecules. |
Annotation:
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