Aging Overview

Aging gene

Gene name: RHEB
Aging type: Prevent
Aging characteristic:
Tissue type: Bone
Cell name: Articular Chondrocyte
Gene ID: 6009
Category: protein coding
Phenotype: Osteoarthritis
Experimental category: L
PMID: 31229684
Experiment: SA-β-gal activity assay//DAPI staining
Description: RHEB- 9 overexpression not only recovered the morphology of the DCs, but also reduced senescence by 10 35–40 %. RHEB-overexpression also decreased ROS levels.


Regulatory relationship

Target gene: COL2A1//SOX9
Official symbol(s): COL2A1//SOX9
R-AG-Target gene: Upregulation//Upregulation
Subcategory: Unclear
Target gene experiment: Western blot
Target gene description: Importantly, 11 RHEB -overexpression increased the level of COL2A1, which was almost negligible in non-transfected DCs. SOX9 expression also increased with RHEB -overexpressing DCs.

Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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