Gene name: | RHEB |
Aging type: | Prevent |
Aging characteristic: |
Tissue type: | Bone |
Cell name: | Articular Chondrocyte |
Gene ID: | 6009 |
Category: | protein coding |
Phenotype: | Osteoarthritis |
Experimental category: | L |
PMID: | 31229684 |
Experiment: | SA-β-gal activity assay//DAPI staining |
Description: | RHEB- 9 overexpression not only recovered the morphology of the DCs, but also reduced senescence by 10 35–40 %. RHEB-overexpression also decreased ROS levels. |
Target gene: | COL2A1//SOX9 |
Official symbol(s): | COL2A1//SOX9 |
R-AG-Target gene: | Upregulation//Upregulation |
Subcategory: | Unclear |
Target gene experiment: | Western blot |
Target gene description: | Importantly, 11 RHEB -overexpression increased the level of COL2A1, which was almost negligible in non-transfected DCs. SOX9 expression also increased with RHEB -overexpressing DCs. |
Regulatory pathway: | -- |
R-AG-Pathway: | -- |
Pathway experiment: | -- |
Pathway description: | -- |
Annotation:
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