| Gene name: | CBX7 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | SGC-7901 |
| Gene ID: | 23492 |
| Category: | protein coding |
| Phenotype: | Gastric cancer |
| Experimental category: | L |
| PMID: | 20723236 |
| Experiment: | Colony formation assay//SA-β-gal activity assay//Western blot//Knockdown |
| Description: | Western blot analysis of CBX7 indicted that CBX7 siRNA efficiently knockdowned CBX7 expression.Stable expression of CBX7 siRNA in SGC-7901 cells led to an increase of senescence and a decrease in colony formation in soft agar.Compared to control, the rate of senescent cells was higher in CBX7 knockdown SGC-7901 cells , and the soft agar colonies in CBX7 knockdown SGC-7901 cells were less in frequency and also smaller in size. |
| Target gene: | P16 |
| Official symbol(s): | P16 |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot//SA-β-gal activity assay |
| Target gene description: | Cell lines with low or no p16(INK4a) overexpressing CBX7 suggested a negative correlation between the expression of CBX7 and p16(INK4a).We found that knockdown of CBX7 resulted in increased p16(INK4a) expression. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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