| Gene name: | PSMB5 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | B-MSC |
| Experiment: | SA-β-gal activity assay//BrdU assay//Western blot |
| Description: | The number of BrdU+ cells was significantly increased by 14% following PSMB5 overexpression (p < 0.01 vs. GFP control),Meanwhile, overexpressing PSMB5 attenuated the reduction of Cyclin D1 and CDK4 proteins, raising their expressions by 56% and 23%, respectively.The SA-β-gal assay was applied to identify the aged hBMSCs by staining them blue. Enhanced proteasomal activity by PSMB5 overexpression significantly reduced the percentage of blue cells from 55 ± 3% to 40 ± 4%. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
Loading,please wait...