| Gene name: | CDK5 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | Saos-2 |
| Experiment: | SA-β-gal activity assay//Knockdown |
| Description: | SiCDK5 or dnCDK5 partially inhibited this activity, and interestingly, CDK5 overexpression enhanced the number of SA-β-Gal-positive cells. |
| Target gene: | RAC1 |
| Official symbol(s): | RAC1 |
| R-AG-Target gene: | Downregulation |
| Subcategory: | Unclear |
| Target gene experiment: | SA-β-gal activity assay |
| Target gene description: | In the presence of activated Rac1, most pRb induction of SA-β-Gal was compromised, a phenotype that was exacerbated by expression of dnCDK5, roscovitine, or siCDK5 treatment . Coexpression of CDK5 with pRb and RacV12 resulted in a partial rescue of SA-β-Gal expression, suggesting that CDK5 might be antagonizing some aspect of Rac1 function. However, in cells transfected with RB and RacN17, coexpression of dnCDK5 and siCDK5 or roscovitine treatment in no way inhibited pRbinduced SA-β-Gal expression. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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