| Gene name: | FUNDC1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HeLa |
| Experiment: | SA-β-gal activity assay//Knockdown |
| Description: | To test the effect of FUNDC1-/HSC70-mediated pathway on cell fate, we established a model of senescence by treating HeLa cells with MG132 for 8 h and then incubating them in normal complete medium for a further 3 days. More than 20% of the cells displayed SA-β-gal-positive staining. |
| Target gene: | AMPK |
| Official symbol(s): | PRKAA2 |
| R-AG-Target gene: | Activation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | Immunoblotting analysis showed that the AMPK activity and the levels of oxidized proteins in MG132-pulse-treated cells were consistently higher than those in control cells until 3 days after treatment withdrawal. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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