| Gene name: | SOX1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HONE1 |
| Gene ID: | 6656 |
| Category: | protein coding |
| Phenotype: | Nasopharyngeal carcinoma |
| Experimental category: | L |
| PMID: | 25427424 |
| Experiment: | SA-β-gal activity assay//Flow cytometry |
| Description: | We also found that overexpression of SOX1 in HONE1 cells enhanced SA-β-gal staining.Ectopic expression of SOX1 increased the number of cells in the G1/G0 phase (from 67.77?±?0.9% to 71.82?±?1.05%) and decreased the number of cells in the G2/M phase (from 12.7?±?0.10% to 9.3?±?0.10%) in HONE1 cells. |
| Target gene: | C-MYC//CYCLIN D1//P21//P27//CYCLIN E |
| Official symbol(s): | C-MYC//CYCLIN D1//P21//P27//CYCLIN E |
| R-AG-Target gene: | Downregulation//Downregulation//Upregulation//Upregulation//Downregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | A decrease in both c-Myc and Cyclin D1 protein was detected in SOX1-overexpressing HONE1 cells.In HONE1 cells, SOX1 overexpression significantly enhanced the expression of p21 and p27 but suppressed the expression of Cyclin E. |
| Regulatory pathway: | WNT-β-CATENIN |
| R-AG-Pathway: | Downregulation |
| Official symbol(s): | Wnt-CTNNB1 |
| Pathway experiment: | Western blot//Knockdown |
| Pathway description: | Furthermore, the down-regulation of β-catenin induced by SOX1-overexpression was reversed by knockdown of SOX1 using siRNA. Consistently, β-catenin was down-regulated in a dose-dependent manner with increasing amounts of SOX1. |
Annotation:
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