Aging Overview

Aging gene

Gene name: CALR
Aging type: Prevent
Aging characteristic:
Tissue type: --
Cell name: ESC
Gene ID: 811
Category: protein coding
Phenotype: Decidualization of Human Endometrial Stromal Cell
Experimental category: L
PMID: 24169561
Experiment: SA-β-gal activity assay//Western blot//Knockdown//Cell morphological analysis
Description: The intensity of SA-β-Gal staining was significantly increased in the CRT siRNA-treated group compared with the control.When the expression of p53 and p21 was examined in these cells, knockdown of CRT suppressed p53 levels and increased p21 levels.Double knock-down of CRT and p21 reduced the ratio of SA-β-Gal-positive cells when compared with single knockdown of CRT.


Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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