| Gene name: | DCLRE1B |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | IMR-90 |
| Experiment: | SA-β-gal activity assay//Knockdown//Western blot//BrdU assay |
| Description: | The arrested Apollo knockdown cells had a senescent morphology and expressed SA-β-galactosidase, a marker for cellular senescence.In addition, all Apollo shRNAs induced the upregulation of the CDK inhibitor p21, a read-out for p53 activation.Primary human IMR90 fibroblasts with diminished Apollo mRNA levels showed a clear growth defect.Within a week of introduction of Apollo shRNAs, the cells gradually slowed their proliferation and appeared to arrest. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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