| Gene name: | ZNF365 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MEF |
| Gene ID: | 22891 |
| Category: | protein coding |
| Phenotype: | Breast cancer |
| Experimental category: | HL |
| PMID: | 23776040 |
| Experiment: | SA-β-gal activity assay//Knockdown//Telomere length assay//Western blot |
| Description: | Upon knockdown of ZNF365, numerous 53BP1-positive foci appeared, with many localizing to telomeres, and cultures showed robust activation of p53 as well as an early-senescent phenotype. To measure the degree of telomere dysfunction, we determined the anaphase bridge index (ABI) out of total late anaphase. ZNF365-depleted TKO cells exhibited a high ABI, indicating the presence of unseparated sister chromatids or DNA bridges. |
| Target gene: | P53 |
| Official symbol(s): | P53 |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Knockdown//Western blot//SA-β-gal activity assay//FISH |
| Target gene description: | Upon knockdown of ZNF365, numerous 53BP1-positive foci appeared, with many localizing to telomeres, and cultures showed robust activation of p53 as well as an early-senescent phenotype . |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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