| Gene name: | NOTCH1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HMVEC,HAEC |
| Gene ID: | 4851 |
| Category: | protein coding |
| Phenotype: | Atherosclerosis |
| Experimental category: | HL |
| PMID: | 23078884 |
| Experiment: | Cell morphological analysis//SA-β-gal activity assay |
| Description: | We tested the effect of enforced activation of Notch1 signaling on HAEC proliferation and observed that Notch activation resulted in significantly retarded cell growth and induced an enlarged, flattened and dendritic senescent morphology.Notch activation resulted in EC senescence since more senescent((β-gal﹢) cells were detectable from NICeGFP/HMVEC and NICeGFP/HAEC than GFP/HMVEC and GFP/HAEC. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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