| Gene name: | ATRX |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | WD/DDLS |
| Experiment: | SA-β-gal activity assay//SAHF//qPCR//Crystal violet assay |
| Description: | Reducing ATRX in these cells affect the accumulation of SA-β-gal-positive cells, SAHF-positive cells, the accumulation of three of the four mRNAs (CXCL1, GM-CSF, IL-6, and IL-8) that increase as part of the SASP in LS8817 cells, and the ability of the cells to return to the cell cycle following drug removal and replating. |
| Target gene: | HRAS |
| Official symbol(s): | HRAS |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | qRT-PCR//CHIP-seq |
| Target gene description: | ATRX binding was strongly enriched at the HRAS locus in senescent LS8817 but not quiescent LS8107 cells.Consistent with the importance of ATRX for repression, HRAS expression increased when ATRX was knocked down in cells that were already senescent. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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