| Gene name: | SPRY1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | Thyroid gland |
| Cell name: | -- |
| Experiment: | SA-β-gal activity assay |
| Description: | Virtually all follicular cells from wild-type mice were strongly positive for SA-β-Gal activity, whereas only a minority of cells from knockout mice was faintly stained. together with increased Ki67 labeling of knockout follicular cells and increased proliferation in vitro,suggest that these cells bypass a program of cellular senescence engaged in the normal thyroid glands. |
| Regulatory pathway: | NF-κB |
| R-AG-Pathway: | -- |
| Official symbol(s): | NFKB1 |
| Pathway experiment: | Western blot |
| Pathway description: | Levels of IkBa, which is responsible for retention of NFkB dimers in the cytoplasm, were increased in the knockout thyroid.IkBa degradation was not impaired, IkBa levels after LPS challenging remained higher in thyroids from knockout mice when compared with wild-type mice. |
Annotation:
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