| Gene name: | HSP90B1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | IMR-90,HFF |
| Gene ID: | 7184 |
| Category: | protein coding |
| Phenotype: | Lung cancer |
| Experimental category: | HL |
| PMID: | 27793846 |
| Experiment: | Knockdown//SA-β-gal activity assay |
| Description: | Regardless of the concentration, GA treatment doubled or tripled the amount of β-galactosidase-positive senescent IMR90 fibroblasts and HFFs compared to controls.As expected, HSP90α or β knockdown by isoform-specific HSP90 siRNAs accelerated cellular senescence. |
| Target gene: | P14 |
| Official symbol(s): | P14 |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | GA treatment or HSP90 ablation induced an increase in p14ARF protein levels and prolonged the half-life of the p14ARF protein under cycloheximide (CHX) treatment in the human cervical cancer cell line HeLa. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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