| Gene name: | LINC-PINT |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HCC,SPHC,SMMC-7721,MHCC-97H |
| Gene ID: | 378805 |
| Category: | ncRNA |
| Phenotype: | Hepatocellular carcinoma |
| Experimental category: | L |
| PMID: | 33754036 |
| Experiment: | IHC//Western blot//DNA FISH//Flow cytometry//SA-β-gal activity |
| Description: | Our results confirmed that Ki67 was remarkably lower in the PINT87aa overexpression group.CircPINT less expressed in proliferating than senescent SMMC-7721 and MHCC-97H cells.CircPINT expression in proliferating and senescent SMMC-7721 and MHCC-97H cells.The proportion of G1 phase cells was increased in PINT87aa-overexpressing cells.SA-β-gal staining showed a higher proportion of cellular senescence in HCC tissues with increased PINT87aa expression. |
| Target gene: | FOXM1//PHB2 |
| Official symbol(s): | FOXM1//PHB2 |
| R-AG-Target gene: | Downregulation//Downregulation |
| Subcategory: | Binding to promoter |
| Target gene experiment: | Co-IP//immunfluorescence experiments |
| Target gene description: | PINT87aa could bind to the DNA-binding domain of FOXM.We observed co-localization of PINT87aa and FOXM1. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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