| Gene name: | IGF1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | Myocyte |
| Gene ID: | 3479 |
| Category: | protein coding |
| Phenotype: | Cardiomyopathy and heart failure |
| Experimental category: | L |
| PMID: | 14726476 |
| Experiment: | Western blot//Telomere length assay |
| Description: | IGF-1 interfered with the age-dependent increases in myocyte size, telomeric shortening and p16INK4aand p53 proteins. |
| Regulatory pathway: | PI3K-AKT |
| R-AG-Pathway: | Activation |
| Official symbol(s): | PIK3CA-AKT1 |
| Pathway experiment: | Western blot |
| Pathway description: | Akt protein (total) remained constant and did not differ in WT and TG myocytes. However, phospho-Akt levels decreased in WT and increased in TG myocytes from 4 to 20 to 22 months. |
Annotation:
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