| Gene name: | PGR |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | ES‐2 |
| Gene ID: | 5241 |
| Category: | protein coding |
| Phenotype: | Ovarian cancer |
| Experimental category: | HL |
| PMID: | 23574718 |
| Experiment: | SA-β-gal activity assay//Cell cycle analysis//Flow cytometry |
| Description: | PH 6.49 GFP-PR cells exposed to R5020 for 4 d significantly induced SAβGal (40%) relative to minimal SAβGal (10%) in empty vector and vehicle-treated cellsc;ell cycle analysis of GFP-PR cells by propidium iodide staining for DNA content demonstrated a significant increase in the percentage of cells in the G0/G1?phase accompanied with a decrease in the percentage of cells in the S phase of the cell cycle following 4 d of ligand exposure relative to vehicle controls. |
| Target gene: | P21//FOXO1 |
| Official symbol(s): | P21//FOXO1 |
| R-AG-Target gene: | Upregulation//-- |
| Subcategory: | Unclear |
| Target gene experiment: | qRT-PCR//Western blot//Knockdown//CHIP |
| Target gene description: | Notably, in the presence of progestin, p21 exhibited significantly increased mRNA and protein expression;p21 mRNA levels were greatly diminished in cells expressing sh-FOXO1 relative to sh-controls in both vehicle- and R5020-treated conditions. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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