| Gene name: | TAZ |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | LN-229 |
| Gene ID: | 6901 |
| Category: | protein coding |
| Phenotype: | Glioblastoma |
| Experimental category: | HL |
| PMID: | 30542117 |
| Experiment: | SA-β-gal activity assay//Knockdown |
| Description: | TAZ knockdown reduces the expression of CTGF and Cyr61 in these cells. Under this circumstance, more LN229 cells undergo senescence after irradiation. Notably, reduction of TAZ expression per se is not sufficient to mimic radiation in inducing senescence, although a modestly increased senescence frequency was observed. Therefore, inhibition of TAZ could facilitate tumor cells to undergo senescence after irradiation. |
| Regulatory pathway: | WNT |
| R-AG-Pathway: | Downregulation |
| Official symbol(s): | Wnt |
| Pathway experiment: | Western blot |
| Pathway description: | To test if radiation-induced TAZ degradation is through inhibiting the Wnt signaling, we first examined the expression of βcatenin. Similar to TAZ, the protein level of β-catenin was also reduced progressively in response to irradiation in LN229 cells. |
Annotation:
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