| Gene name: | SPI1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | BJ,WI-38 |
| Gene ID: | 6688 |
| Category: | protein coding |
| Phenotype: | Acute leukemia |
| Experimental category: | L |
| PMID: | 28912174 |
| Experiment: | SA-β-gal activity assay//Western blot |
| Description: | The ectopic expression of Spi1 or HRASV12 both led to senescence that was characterized by stable cell cycle arrest, increased senescence-associated betagalactosidase (SA-βgal) activity, as measured by cytochemical staining and cytometric analyses, and increased protein levels of the senescence biomarker Dec1. |
| Regulatory pathway: | P38 MAPK |
| R-AG-Pathway: | Activation |
| Official symbol(s): | MAKP14 |
| Pathway experiment: | GFP localization assay |
| Pathway description: | The treatment of Spi1 overexpressing cells with SB203580 also increased, although partially, the number of GFP-positive cells, indicating that p38MAPK14 controls senescence and additional mechanisms modulating cell number. |
Annotation:
Loading,please wait...