| Gene name: | CDKN2A |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | Kidney |
| Cell name: | Renal cell |
| Gene ID: | 1029 |
| Category: | protein coding |
| Phenotype: | Renal tubulointerstitial injury |
| Experimental category: | HL |
| PMID: | 28790310 |
| Experiment: | Immunostaining//SA-β-gal activity assay//Knockdown//qRT-PCR//Western blot |
| Description: | P16 deletion was significantly rescued the abnormalities in renal cell proliferation, apoptosis and senescence, DNA damage and inflammatory cell infiltration observed in Bmi-1 -/- mice.However,they were reduced significantly in Bmi-1-/- p16 -/- mice compared with Bmi-1-/- mice.These results demonstrated that p16 deletion ameliorated the proinflammatory secretory phenotype caused by Bmi-1 deficiency. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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