| Gene name: | CNOT6L |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MCF-7 |
| Experiment: | SA-β-gal activity assay//Knockdown |
| Description: | Consistent with the role of IGFBP5, knockdown of Ccr4a/Ccr4b caused a significant increase in senescence-associated β-galactosidase staining as compared with control or Caf1a/Caf1b knockdown. |
| Target gene: | IGFBP5 |
| Official symbol(s): | IGFBP5 |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Knockdown//qRT-PCR |
| Target gene description: | We confirmed enhanced expression of IGFBP5 (approximately threefold), CLEC3A (approximately threefold), SEMA3E (approximately twofold), MAPK10 (approximately twofold), CDH18 (approximately twofold), and LMO3 (approximately eightfold) upon Ccr4a/Ccr4b knockdown. |
| Regulatory pathway: | P53 |
| R-AG-Pathway: | -- |
| Official symbol(s): | TP53 |
| Pathway experiment: | Western blot//Knockdown |
| Pathway description: | Interestingly, while the overall levels of both total p53 as well as p53 acetylated at Lys-120 were significantly increased in Ccr4a/Ccr4b knockdown cells, the fraction of p53 acetylated at Lys-120 was not increased. |
Annotation:
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