| Gene name: | BCL2L12 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MEF |
| Gene ID: | 83596 |
| Category: | protein coding |
| Phenotype: | Glioblastoma |
| Experimental category: | L |
| PMID: | 20837658 |
| Experiment: | SA-β-gal activity assay//Flow cytometry |
| Description: | Bcl2L12-expressing MEFs exhibited unabated growth for >35 passages, whereas control cultures showed significantly reduced growth rates or underwent growth arrest with coincidental increase in senescence-associated β-galactosidase (SA-β-Gal) activity . |
| Regulatory pathway: | P53 |
| R-AG-Pathway: | Downregulation |
| Official symbol(s): | TP53 |
| Pathway experiment: | Western blot |
| Pathway description: | Prompted by the molecular p53 pathway analyses in DNA-damaged MEFs showing reduced p53 accumulation in the presence of Bcl2L12. |
Annotation:
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