| Gene name: | CHEK2 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HFF,IMR-90 |
| Experiment: | Knockdown//SA-β-gal activity assay//BrdU assay |
| Description: | Knockdown of endogenous Chk2 protein led to short-term responses equivalent to those seen with the dominant-negative Chk2, namely reversion to a‘young’ morphology, reduced SA-β-gal expression and increased BrdU incorporation. |
| Target gene: | P21//RB//CYCLIN A |
| Official symbol(s): | P21//RB//CYCLIN A |
| R-AG-Target gene: | Downregulation//--//Upregulation |
| Subcategory: | Phosphorylation |
| Target gene experiment: | Western blot |
| Target gene description: | We observed a reduction of p21 protein level,and an increase in the hyperphosphorylated form of Rb and in cyclin A expression compared to age-matched control HFF. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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