| Gene name: | SUV39H1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | Fibroblast |
| Experiment: | Western blot//SA-β-gal activity assay |
| Description: | Among these, SUV39H1, a histone methyltransferase that specifically methylates H3K9 and was previously associated with functions in aging or senescence (S4), was downregulated in senescent cells (PD 54), as confirmed by Western blot analysis. Further, the surviving cells in PD 47 cultures treated with increasing concentrations of chaetocin became senescent, suggesting that the inhibition of SUV39H1 was sufficient to induce senescence in low PD cells. |
| Target gene: | P21 |
| Official symbol(s): | P21 |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot//CHIP |
| Target gene description: | p21 protein levels were increased in senescent cells and correlated with the reduced expression levels of SUV39H1.Further, H3K9me3 was less abundant in the promoter region of IL6 in senescent cells when compared to dividing cells,as determined by ChIP, suggesting that reduced SUV39H1 expression levels affect the gene expression profiles of senescent cells. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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