| Gene name: | TP53 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | Spine,tibias,Skin |
| Cell name: | HSC |
| Experiment: | Histological staining//Flow cytometry//BrdU assay |
| Description: | P72 mice showed a delayed development of all these aging-related changes compared with R72 mice, with the most obvious differences observed at the age of 18 months.R72 mice showed more significant decreases in both skin dermal thickness and subcutaneous adipose thickness compared with P72 mice.R72 mice showed a more rapid increase in the numbers of LT-HSCs than P72 mice during aging.While there was no significant difference in LT-HSC numbers between young 129SVslR72 and P72 mice, much higher LT-HSC numbers were observed in R72 mice than P72 mice at the age of both 12 and 18 months.The decrease of proliferation HSCs was more rapid in R72 mice than P72 mice during aging .R72 mice displayed a more obvious sign of osteoporosis than P72 mice.However, 12- and 18-month-old R72 mice showed a more pronounced decrease in the wound healing ability than age-matched P72 mice.Notably, 18-month-old R72 mice developed more pronounced lordokyphosis compared with age-matched P72 mice. |
| Target gene: | P21 |
| Official symbol(s): | P21 |
| R-AG-Target gene: | Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | RT-PCR//Western blot |
| Target gene description: | p21 mRNA expression levels in the bone marrow were slightly higher in P72 mice compared with R72 mice as determined by real-time PCR assays with this difference being more obvious in older mice than young mice. This difference in p21 expression levels was confirmed at the protein level as determined by Western-blot assays. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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