| Gene name: | ING1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | Fibroblast |
| Experiment: | SA-β-gal activity assay//Cell morphological analysis |
| Description: | Retroviral transduction with p33ING1 resulted in a change to senescence-like cell morphology, as documented by phase-contrast microscopy.We tested for expression of SA-β-Gal activity in p33ING1-infected primary human fibroblasts by use of RasV12 as a control. In accordance with the previous observations, p33ING1 induces SA-β-Gal activity to a extent similar to that seen with oncogenic Ras, suggesting that p33ING1 has potency similar to that of RasV12. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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