Aging Overview

Aging gene

Gene name: DUSP1
Aging type: Accelerate
Aging characteristic:
Tissue type: --
Cell name: SO-Rb5
Gene ID: 1843
Category: protein coding
Phenotype: Aging
Experimental category: L
PMID: 30536303
Experiment: SA-β-gal activity assay//Knockdown
Description: DUSP1 plasmid and siRNA transfection enhanced and attenuated SO-Rb5 cell senescence induced by AGII, respectively, revealing that DUSP1 participated in SO-Rb5 cell senescence induced by AGII.


Regulatory relationship

Regulatory pathway: AKT
R-AG-Pathway: Downregulation
Official symbol(s): AKT1
Pathway experiment: Western blot
Pathway description: DUSP1 plasmid and siRNA transfection inhibited and strengthened Akt signaling in SO-Rb5 cell senescence induced by AGII, respectively, revealing that DUSP1 participated in SO-Rb5 cell senescence induced by AGII.


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



Pathway view

About risk SNP and eQTL

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