Aging Overview

Aging gene

Gene name: SETD1A
Aging type: Prevent
Aging characteristic:
Tissue type: --
Cell name: MDA-MB-231
Gene ID: 9739
Category: protein coding
Phenotype: Aging
Experimental category: HL
PMID: 31253781
Experiment: Cell proliferation assay//SA-β-gal activity assay//Knockdown
Description: Remarkably, knockdown of SETD1A(SETD1A-KD) suppresses proliferation and triggers prompt (72h) and massive cellular senescence, with very large cells expressing characteristic ?-galactosidase (?-gal) activity.


Regulatory relationship

Target gene: SKP2
Official symbol(s): SKP2
R-AG-Target gene: --
Subcategory: Methylation
Target gene experiment: Western blot//qPCR//SA-β-gal activity assay
Target gene description: We first confirmed that endogenous SKP2 mRNA and protein are indeed suppressed in MDA-MB-231 cells following SETD1A-KD:taining for ?-Galactosidase shows that induction of SKP2 partially suppressed the emergence of ?-Gal-positive senescent cells by 50% following SETD1A-KD.

Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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