Aging Overview

Aging gene

Gene name: IRF3
Aging type: Accelerate
Aging characteristic: Others
Tissue type: --
Cell name: BJ,IMR-90
Gene ID: 3661
Category: protein coding
Phenotype: Aging
Experimental category: L
PMID: 16513254
Experiment: Cell counting//SA-β-gal activity assay//Knockdown
Description: overexpression of IRF3 in BJ and IMR90 cells was shown to decrease the rate of cell proliferation and increase the senescence cell population,as determined by senescence-associated β-galactosidase staining assay.When the cellular life span was determined by 3T6 cell culture protocol, IRF3-knockdown BJ cells were found to increase the cell proliferation rate and life span.


Regulatory relationship

Target gene: P53
Official symbol(s): P53
R-AG-Target gene: Activation
Subcategory: Unclear
Target gene experiment: Western blot
Target gene description: We found that p53 mRNA was not increased by IRF3, but p53 protein and its downstream target p21WAF1 were upregulated in IRF3-overexpressing BJ cells.

Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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