Aging Overview

Aging gene

Gene name: FOXQ1
Aging type: Prevent
Aging characteristic:
Tissue type: Umbilical cord
Cell name: HUCMSC
Gene ID: 94234
Category: protein coding
Phenotype: Alzheimer's disease
Experimental category: L
PMID: 29500491
Experiment: CCK-8 assay//Cell morphological analysis//SA-β-gal activity assay//qRT-PCR//Western blot//PI staining
Description: Cell viability was significantly enhanced in the P15-FOXQ1 group compared with that in the P15-vector group on day 4.Meanwhile, the morphology of cells in the P15-FOXQ1 group was changed slightly compared with those in the P3 group,with the spindle shape maintained in most cells. The number of SA-β-gal-positive cells was noticeably reduced in the P15-FOXQ1 group.Compared with the P15-vector group,expression of positive senescence-associated genes such as p16,p21 and p53 was down-regulated at the mRNA level. At the mRNA and protein level,Expression of negative senescence-associated genes, such as SIRT1 and PCNA, was up-regulated.A significantly higher number of cells in the S phase and M phase was detected in the P15-FOXQ1 group compared with that in the P15-vector group.


Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

Loading,please wait...