Gene name: | FOXQ1 |
Aging type: | Prevent |
Aging characteristic: |
Tissue type: | Umbilical cord |
Cell name: | HUCMSC |
Gene ID: | 94234 |
Category: | protein coding |
Phenotype: | Alzheimer's disease |
Experimental category: | L |
PMID: | 29500491 |
Experiment: | CCK-8 assay//Cell morphological analysis//SA-β-gal activity assay//qRT-PCR//Western blot//PI staining |
Description: | Cell viability was significantly enhanced in the P15-FOXQ1 group compared with that in the P15-vector group on day 4.Meanwhile, the morphology of cells in the P15-FOXQ1 group was changed slightly compared with those in the P3 group,with the spindle shape maintained in most cells. The number of SA-β-gal-positive cells was noticeably reduced in the P15-FOXQ1 group.Compared with the P15-vector group,expression of positive senescence-associated genes such as p16,p21 and p53 was down-regulated at the mRNA level. At the mRNA and protein level,Expression of negative senescence-associated genes, such as SIRT1 and PCNA, was up-regulated.A significantly higher number of cells in the S phase and M phase was detected in the P15-FOXQ1 group compared with that in the P15-vector group. |
Regulatory pathway: | -- |
R-AG-Pathway: | -- |
Pathway experiment: | -- |
Pathway description: | -- |
Annotation:
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