| Gene name: | SIRT6 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | U2OS |
| Experiment: | SA-β-gal activity assay |
| Description: | We detected significantly increased numbers of senescent U2OS cells (over ~20-fold higher than those of control cells) within a week of SIRT6 depletion by lentiviral short hairpin RNAs (shRNAs). |
| Target gene: | H3K18AC |
| Official symbol(s): | H3K18AC |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | SIRT6 also promoted H3K18ac deacetylation when overexpressed in cells, whereas the mutant SIRT6 H133Y protein did not.Together, these data identify H3K18ac as a new chromatin substrate of SIRT6 and demonstrate a physiologic role of SIRT6 in maintaining total cellular levels of this histone mark. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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