Aging Overview

Aging gene

Gene name: AKAP4
Aging type: Prevent
Aging characteristic:
Tissue type: --
Cell name: COLO 205 ,HCT116
Gene ID: 8852
Category: protein coding
Phenotype: Colorectal cancer
Experimental category: L
PMID: 26590805
Experiment: SA-β-gal activity assay//Knockdown//Western blot
Description: The percentage of senescent cells was significantly higher in COLO 205 (44.2 %) and HCT 116 cells (48.4 %) when transfected with AKAP4 shRNA3 as compared to NC shRNA staining . AKAP4 ablation also resulted in the upregulation of decoy receptor 2 (DCR2) protein expression which is a marker for cellular senescence.


Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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