Gene name: | AKAP4 |
Aging type: | Prevent |
Aging characteristic: |
Tissue type: | -- |
Cell name: | COLO 205 ,HCT116 |
Gene ID: | 8852 |
Category: | protein coding |
Phenotype: | Colorectal cancer |
Experimental category: | L |
PMID: | 26590805 |
Experiment: | SA-β-gal activity assay//Knockdown//Western blot |
Description: | The percentage of senescent cells was significantly higher in COLO 205 (44.2 %) and HCT 116 cells (48.4 %) when transfected with AKAP4 shRNA3 as compared to NC shRNA staining . AKAP4 ablation also resulted in the upregulation of decoy receptor 2 (DCR2) protein expression which is a marker for cellular senescence. |
Regulatory pathway: | -- |
R-AG-Pathway: | -- |
Pathway experiment: | -- |
Pathway description: | -- |
Annotation:
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