| Gene name: | ITPR2 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MRC5 |
| Experiment: | SA-β-gal activity assay//EdU assay//qRT-PCR//Western blot//RNA-seq |
| Description: | To further confirm a link between the loss of Itpr2 and decreased levels of senescence, beyond the liver, we explored the replicative potential of Itpr2 KO- and WT-derived MEFs. Late passage Itpr2 KO MEFs showed a decreased level of cellular senescence, as illustrated by a decrease in the level of several cellular senescence markers, namely the senescence associated-β-galactosidase activity (SA-β-Gal) (Fig. 2g and Supplementary Fig. 2c), cell proliferation (Supplementary Fig. 2d), p16ink4a mRNA (Fig. 2h) and protein (Fig. 2i) levels and finally a reversion of the enhanced inflammatory response as evidenced by transcriptomic data |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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