| Gene name: | HGF |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | hE-MSC,BM-MSC |
| Gene ID: | 3082 |
| Category: | protein coding |
| Phenotype: | Liver disease |
| Experimental category: | L |
| PMID: | 29398486 |
| Experiment: | qRT-PCR//FISH |
| Description: | RTL was analyzed after treating hE-MSCs with a neutralizing HGF antibody.Telomere length was decreased to 50% and PDT was delayed to 80 hr upon loss of HGF function in hE-MSCs.Interphase telomere fluorescence in situ hybridization (FISH) showed that treatment of hBM-MSCs with rHGF increased the number and intensity of PNA foci in the nucleus.After normalization to AIB1, a reference gene with only a single copy on the chromosome, the relative mtDNA copy number was 1.5-fold higher in rHGF-treated cells than in control cells. |
| Target gene: | RAD51 |
| Official symbol(s): | RAD51 |
| R-AG-Target gene: | Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | HR assay//Western blot |
| Target gene description: | When we treated hBM-MSCs with rHGF, the activity and protein level of RAD51 increased.When we blocked HGF in hE-MSCs using a neutralizing antibody,the protein level of RAD51 decreased. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
Loading,please wait...