| Gene name: | BAP1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HeLa-S3 |
| Gene ID: | 8314 |
| Category: | protein coding |
| Phenotype: | Cervical cancer |
| Experimental category: | L |
| PMID: | 26416890 |
| Experiment: | SA-β-gal activity assay |
| Description: | Strikingly, retroviral overexpression of BAP1 reduced cell proliferation and induced senescence-associated β-galactosidase (SA-β-gal) activity. |
| Target gene: | ASXL1/2 |
| Official symbol(s): | ASXL1 |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | We found that BAP1 protein levels increased with ASXL1/2 expression in a dose-dependent manner. Conversely, ASXL1/2 protein levels were also increased following overexpression of BAP1. |
| Regulatory pathway: | P53-P21 |
| R-AG-Pathway: | -- |
| Official symbol(s): | TP53-CDKN1A |
| Pathway experiment: | Western blot |
| Pathway description: | We found that although the effect of BAP1 was less pronounced than the BAP1C91S?form, overexpression of this DUB induced the p53/p21 tumor suppressor pathway.Overexpression of BAP1ΔCTD, BAP1R666-H669, BAP1C91S-ΔCTD, or BAP1C91S-R666-H669?did not up-regulate p53/p21 indicating the requirement for ASXL1/2 in BAP1-mediated senescence . |
Annotation:
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