| Gene name: | DKC1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | A549 cells,PC-9 cells |
| Experiment: | SA-β-gal activity assay//Western blot |
| Description: | There was more senescence associated β-galactosidase positive cells in DKC1 silenced A549 and PC-9 cells, and the expression of cell senescence and apoptosis marker P21 and DNA damage marker γH2A. X are higher in A549 and PC-9 cells with DKC1 downregulation compared to control cells. |
| Target gene: | TERC |
| Official symbol(s): | TERC |
| R-AG-Target gene: | Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | SA-β-gal activity assay//Western blot//qPCR//Spearman's rank correlation analysis |
| Target gene description: | Both the level of TERC and telom- erase activity were significantly decreased in DKC1 silenced A549 and PC-9 cells. In accordance with this phenomenon, DKC1 downregulated A549 and PC-9 cells showed reduced length of tel- omere. There was more senescence associated β-galactosidase positive cells in DKC1 silenced A549 and PC-9 cells, and the expression of cell senescence and apoptosis marker P21 and DNA damage marker γH2A. X are higher in A549 and PC-9 cells with DKC1 downregulation compared to control cells. Both telomerase RNA component (TERC) and telomerase reverse transcriptase (TERT) expression were positively correlated with DKC1 expression in TCGA datasets. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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