| Gene name: | CDKN2A |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MSC |
| Gene ID: | 1029 |
| Category: | protein coding |
| Phenotype: | Systemic Lupus Erythematosus |
| Experimental category: | L |
| PMID: | 22820504 |
| Experiment: | SA-β-gal activity assay//Knockdown//Flow cytometry//BrdU assay |
| Description: | There were less SA-β-gal-positive cells when p16INK4A expression was knocked down in MSCs from SLE patients. The cell proliferation assay showed that the proliferation rate of p16INK4A knockdown MSCs from SLE patients was restored to that of the normal MSCs. Cell-cycle analysis revealed that G1 phase arrest was reversed in p16INK4A-knockdown MSCs from SLE patients . |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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