Aging Overview

Aging gene

Gene name: GRK4
Aging type: Accelerate
Aging characteristic:
Tissue type: --
Cell name: HEK293
Gene ID: 2868
Category: protein coding
Phenotype: Aging
Experimental category: L
PMID: 28912086
Experiment: SA-β-gal activity assay//Immunostaining
Description: The Ki-67 protein were clearly detected within the cell nuclei of GRK4(-) cells and CNE2 cells, whereas it was barely found in GRK4(+) cells. We next assessed the SA-β-gal activity in the GRK4(+) and GRK4(-) cells by a SA-β-gal staining. The stained cells and total cells were counted under an inverted phase microscope and the percentage of cells staining positive was calculated.High stain positive of 99±0.20% in GRK4(+) cells for SA-β-gal was detected , while this was markedly low to only1±0.15% in GRK4(-) cells.


Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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