| Gene name: | SMURF2 |
| Aging type: | Accelerate |
| Aging characteristic: | Others |
| Tissue type: | Foreskin,Skin,Lung,Mammary Gland |
| Cell name: | BJ,WS1,WI-38 |
| Experiment: | Cell counting//SA-β-gal activity assay |
| Description: | Adventitious expression of Smurf2 to the level observed physiologically during replicative senescence resulted in arrest of proliferation of all three lines of early passage fibroblasts in a subconfluent state.During this acute transition, the early passage Smurf2-expressing cells acquired the property of positive staining for β-galactosidase activity at pH 6. |
| Regulatory pathway: | P53//RB |
| R-AG-Pathway: | --//-- |
| Official symbol(s): | TP53//retinoblastoma |
| Pathway experiment: | Cell counting//Cell morphological analysis//SA-β-gal activity assay |
| Pathway description: | The concurrent expression of both E6 and E7 prevent Smurf2 s effects as indicated by cell growth arrest in a subconfluent state, enlarged and flat cell morphology, and positive staining for -galactosidase activity at pH 6. |
Annotation:
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