| Gene name: | RAPGEF4 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | EM1 |
| Experiment: | SA-β-gal activity assay//Western blot//Knockdown |
| Description: | The intensity of SA-β-Gal staining significantly increased in the EPAC2 or CALR siRNA-treated EM1 cells compared with the control cells. Furthermore, knockdown of either EPAC2 or CALR in EM1 cells suppressed the level of p53 but increased the level of p21. |
| Target gene: | CALR |
| Official symbol(s): | CALR |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot//Knockdown |
| Target gene description: | To determine whether knockdown of EPAC2 downregulated expression of CALR protein, the level of CALR in EPAC2-silenced EM1 cells was examined by immunoblot analysis. EPAC2 knockdown significantly suppressed CALR expression. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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