| Gene name: | PPIB |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | U251 |
| Gene ID: | 5479 |
| Category: | protein coding |
| Phenotype: | Glioblastoma |
| Experimental category: | HL |
| PMID: | 24272483 |
| Experiment: | Knockdown//SA-β-gal activity assay |
| Description: | As suggested by these findings, although the majority of U251 cells died upon CypB knockdown, surviving cells showed microscopic changes characteristic of senescence, including large and flat morphology, binuclear cells, and massive vacuolization. Furthermore, CypB knockdown in U87 cells markedly increased SA-β-gal staining.Overexpression of oncogenic Ras (HRASV12) in GBM cells evoked similar senescence-associated morphological and molecular changes. |
| Target gene: | P27 |
| Official symbol(s): | P27 |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Knockdown//Western blot |
| Target gene description: | CypB knockdown or inhibition also increased levels of the cell cycle inhibitor p27/Kip1 (24) and strongly reduced the p27-specific E3 ubiquitin ligase Skp2. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
Loading,please wait...