| Gene name: | CTNNB1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | Ish-bcat#7,Ishikawa,Ish-tet#8 |
| Gene ID: | 1499 |
| Category: | protein coding |
| Phenotype: | Endometrial cancer |
| Experimental category: | L |
| PMID: | 15111320 |
| Experiment: | Immunostaining//SA-β-gal activity assay |
| Description: | Some Ishbcat#7 cells with nuclear β-catenin expression demonstrated increase in size, and were more spread and flattened and multinucleated but not squamoid in appearance .After tetracycline treatment, there was an increase in numbers of senescence-like Ish-tet#8 cells similar to the case with Ish-bcat#7 cells. Four and five days after tetracycline treatment, SA-β-gal-positive cells were significantly increased with Ish-tet#8, but not the mock clones. |
| Target gene: | CYCLIN D1 |
| Official symbol(s): | CYCLIN D1 |
| R-AG-Target gene: | Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | In addition, increased expression of cyclin D but not PML was evident in Ish-bcat#7 cells. |
| Regulatory pathway: | P53-P21 |
| R-AG-Pathway: | Upregulation |
| Official symbol(s): | TP53-CDKN1A |
| Pathway experiment: | Western blot |
| Pathway description: | In addition, increased expression of p53, and p21WAF1 but not PML was evident in Ish-bcat#7 cells. |
Annotation:
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