| Gene name: | KDM3A |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | OVCAR-5,A2780 |
| Gene ID: | 55818 |
| Category: | protein coding |
| Phenotype: | Ovarian cancer |
| Experimental category: | HL |
| PMID: | 27694900 |
| Experiment: | SA-β-gal activity assay//Knockdown//Flow cytometry |
| Description: | Interestingly,KDM3A depletion led to G2/M cell cycle arrest, which was accompanied by increased apoptosis,Since we observed that growth arrest was accompanied by the presence of large, flat and vacuolated cells in KDM3A knockdown cells,Indeed,both OVCAR-5/CDDP and A2780/CDDP cells expressing KDM3A shRNAs showed high abundance of senescence-associated β-galactosidase positive cells as compared with scrambled control cells,indicating that KDM3A prevents the cellular senescence to promote sustained growth of ovarian cancer. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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