| Gene name: | SPRY4 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | Tumor tissue tissue |
| Cell name: | SK-MEL-119NRAS* |
| Gene ID: | 81848 |
| Category: | protein coding |
| Phenotype: | Melanoma |
| Experimental category: | HL |
| PMID: | 30651601 |
| Experiment: | TUNEL assay//SA-β-gal activity assay//Flow cytometry |
| Description: | In vitro analysis of SK-MEL-119NRAS confirmed the increase in apoptosis and SA-β-galactosidase enzyme activity with SPRY4 induction . Compared to control tumors, SPRY4 tumors also harbored reduced Ki67, enhanced tumor cell apoptosis as shown by TUNEL staining and increased SA-β-gal expression. However, upon induction of iBRAF in SK-MEL-119NRAS, there was a significant arrest, as expected, with the control siNTC. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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