| Gene name: | TLR8 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MCF-7,M628,PC-3 |
| Experiment: | SA-β-gal activity assay//Knockdown |
| Description: | Knockdown of TLR8,MyD88, and IRAK4 in tumor cells significantly blocked the Poly-G3-mediated reversal of tumor-induced CD4+T-cell senescence. These results confirmed that TLR8 signaling can prevent the induction of T-cell senescence mediated by tumor cells. |
| Target gene: | CAMP |
| Official symbol(s): | CAMP |
| R-AG-Target gene: | Downregulation |
| Subcategory: | Unclear |
| Target gene experiment: | ELISA |
| Target gene description: | Indeed, Poly-G3 treatment significantly decreased the cAMP levels in tumor cells. Notably, pretreatment of tumor cells with Poly-G3 also markedly decreased the cAMP levels in T cells co-cultured with tumor cells. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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