| Gene name: | UBC |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | BM-MSC |
| Experiment: | SA-β-gal activity assay//Flow cytometry//Knockdown |
| Description: | SA-β-gal-positive senescent cells were accumulated as 4.7±1.9%, 7.8±1.9% and 13.7 ±5.1% at 24, 48 and 72 h after UBC KD, respectively,while they were not increased in NC-transfected cells (2.6 ±1.9%, 2.6±1.3% and 0.8±0.2% after 24, 48 and 72 h, respectively);The impaired proliferation of hBM-MSCs occurred in a UBC dose-dependent manner. |
| Target gene: | HUB |
| Official symbol(s): | HUB |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | qRT-PCR |
| Target gene description: | The hub molecules including CDK1, CCNA2, MCM10, E2F1, HIST1H1A, HIST1H3B and BRCA1 were sequentially decreased during passaging accompanied by the decrement of UBC. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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