| Gene name: | MIR339 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HCT116 |
| Gene ID: | 442907 |
| Category: | ncRNA |
| Phenotype: | Colorectal cancer |
| Experimental category: | L |
| PMID: | 25193859 |
| Experiment: | SA-β-gal activity assay |
| Description: | MiR-339-5p enhanced p53-mediated senescence in HCT116 cells treated with Doxorubicin.The miR-339-5p inhibitor reduced p53-mediated senescence in HCT116 cells treated with Doxorubicin. |
| Target gene: | MDM2//P21//P53 |
| Official symbol(s): | MDM2//P21//P53 |
| R-AG-Target gene: | Downregulation//Upregulation//Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | MiR-339-5p decreased MDM2 protein levels and increased the p53 protein accumulation and transcriptional activity toward p21 in response to stress in HCT116 cells. (C) MiR-339-5p decreased MDM2 protein levels and increased p53, p21 protein levels in response to stress in RKO cells. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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