Gene name: | SAMHD1 |
Aging type: | Prevent |
Aging characteristic: |
Tissue type: | -- |
Cell name: | HeLa |
Gene ID: | 25939 |
Category: | protein coding |
Phenotype: | Aicardi–Goutières syndrome |
Experimental category: | HL |
PMID: | 24445253 |
Experiment: | SA-β-gal activity assay//Knockdown//Flow cytometry//Western blot |
Description: | Depletion of SAMHD1 in HeLa cells by RNA interference led to increased expression of p21. This was accompanied by a delay in cell cycle progression and signs of cellular senescence, as shown by increased β-galactosidase activity. |
Regulatory pathway: | -- |
R-AG-Pathway: | -- |
Pathway experiment: | -- |
Pathway description: | -- |
Annotation:
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