Aging Overview

Aging gene

Gene name: SAMHD1
Aging type: Prevent
Aging characteristic:
Tissue type: --
Cell name: HeLa
Gene ID: 25939
Category: protein coding
Phenotype: Aicardi–Goutières syndrome
Experimental category: HL
PMID: 24445253
Experiment: SA-β-gal activity assay//Knockdown//Flow cytometry//Western blot
Description: Depletion of SAMHD1 in HeLa cells by RNA interference led to increased expression of p21. This was accompanied by a delay in cell cycle progression and signs of cellular senescence, as shown by increased β-galactosidase activity.


Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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